Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1994 1
1997 3
1998 1
2000 3
2001 2
2002 2
2003 2
2004 2
2005 1
2006 1
2007 4
2008 1
2009 6
2010 2
2011 5
2012 2
2013 6
2014 7
2015 11
2016 9
2017 7
2018 5
2019 7
2020 7
2021 6
2022 8
2023 3
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

112 results

Results by year

Filters applied: . Clear all
Page 1
RAD51 Inhibitor and Radiation Toxicity in Vestibular Schwannoma.
Thielhelm TP, Nourbakhsh A, Welford SM, Mellon EA, Bracho O, Ivan ME, Telischi F, Fernandez-Valle C, Dinh CT. Thielhelm TP, et al. Otolaryngol Head Neck Surg. 2022 Nov;167(5):860-868. doi: 10.1177/01945998221083506. Epub 2022 Mar 1. Otolaryngol Head Neck Surg. 2022. PMID: 35230908 Free PMC article.
Viability assays were performed at 96 hours, and capillary Western blotting was utilized to determine RAD51 expression in naive VS tumors (n = 5). RESULTS: VS tumors expressed RAD51. ...Although there was variability in responses among individual primary VS cells, …
Viability assays were performed at 96 hours, and capillary Western blotting was utilized to determine RAD51 expression in naive VS tu …
Primary Vestibular Schwannoma Cells Activate p21 and RAD51-Associated DNA Repair Following Radiation-Induced DNA Damage.
Thielhelm TP, Goncalves S, Welford S, Mellon EA, Bracho O, Estivill M, Brown C, Morcos J, Ivan ME, Telischi F, Fernandez-Valle C, Dinh CT. Thielhelm TP, et al. Otol Neurotol. 2021 Dec 1;42(10):e1600-e1608. doi: 10.1097/MAO.0000000000003322. Otol Neurotol. 2021. PMID: 34420024 Free PMC article.
In this study, we describe how VS cells enter cell cycle arrest (through p21 expression), activate DNA repair (through RAD51 upregulation), and avoid cell death after radiation-induced double-stranded breaks (DSB) in DNA (as measured by gamma-H2AX). ...Viability assays wer …
In this study, we describe how VS cells enter cell cycle arrest (through p21 expression), activate DNA repair (through RAD51 upregula …
Stellettin B Sensitizes Glioblastoma to DNA-Damaging Treatments by Suppressing PI3K-Mediated Homologous Recombination Repair.
Peng X, Zhang S, Wang Y, Zhou Z, Yu Z, Zhong Z, Zhang L, Chen ZS, Claret FX, Elkabets M, Wang F, Sun F, Wang R, Liang H, Lin HW, Kong D. Peng X, et al. Adv Sci (Weinh). 2023 Jan;10(3):e2205529. doi: 10.1002/advs.202205529. Epub 2022 Dec 1. Adv Sci (Weinh). 2023. PMID: 36453577 Free PMC article.
Mechanistically, STELB inhibits the expression of homologous recombination repair (HR) factors BRCA1/2 and RAD51 by promoting the degradation of PI3Kalpha through the ubiquitin-proteasome pathway; and the induced HR deficiency then leads to augmented DNA damage and cell de …
Mechanistically, STELB inhibits the expression of homologous recombination repair (HR) factors BRCA1/2 and RAD51 by promoting the deg …
Microcephaly family protein MCPH1 stabilizes RAD51 filaments.
Chang HY, Lee CY, Lu CH, Lee W, Yang HL, Yeh HY, Li HW, Chi P. Chang HY, et al. Nucleic Acids Res. 2020 Sep 18;48(16):9135-9146. doi: 10.1093/nar/gkaa636. Nucleic Acids Res. 2020. PMID: 32735676 Free PMC article.
Importantly, we demonstrate that MCPH1 enhances the stability of RAD51 on single-strand DNA, a prerequisite step for RAD51-mediated recombination. Single-molecule tethered particle motion analysis showed a 2-fold increase in the lifetime of RAD51-ssDNA filame …
Importantly, we demonstrate that MCPH1 enhances the stability of RAD51 on single-strand DNA, a prerequisite step for RAD51-med …
[RAD51 promotes proliferation and migration of glioblastoma cells and decreases sensitivity of cells to temozolomide].
Li Q, Ru Y, Wang Q, Lyu W, Hu W, Fei Z, Li X, Lin W. Li Q, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Sep;35(9):817-822. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019. PMID: 31750824 Chinese.
Over-expression of RAD51 increased the expression of P53, whereas knockdown of RAD51 decreased the expression of P53. Conclusion RAD51 plays an oncogene function in glioma cells. RAD51 over-expression enhances the proliferation and migration of glioma …
Over-expression of RAD51 increased the expression of P53, whereas knockdown of RAD51 decreased the expression of P53. Conclusi …
Chromosome breakage syndromes and cancer.
Duker NJ. Duker NJ. Am J Med Genet. 2002 Oct 30;115(3):125-9. doi: 10.1002/ajmg.10688. Am J Med Genet. 2002. PMID: 12407692 Review.
Both the chromosomal instabilities and neoplastic outcomes are related to abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis. Among these diseases are ataxia telangectasia and Nijmegen breakage syndrome, with increased incidences of …
Both the chromosomal instabilities and neoplastic outcomes are related to abnormalities of DNA metabolism, DNA repair, cell-cycle governance …
RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.
Westermark UK, Lindberg N, Roswall P, Bråsäter D, Helgadottir HR, Hede SM, Zetterberg A, Jasin M, Nistér M, Uhrbom L. Westermark UK, et al. Neuro Oncol. 2011 Dec;13(12):1277-87. doi: 10.1093/neuonc/nor131. Epub 2011 Sep 16. Neuro Oncol. 2011. PMID: 21926087 Free PMC article.
Expression of RAD51 inhibited proliferation and genomic instability of tumor cells independent of Arf status. Our results demonstrate that the RAD51 pathway can prevent glioma initiation and maintain genome integrity of induced tumors, suggesting reactivation of the …
Expression of RAD51 inhibited proliferation and genomic instability of tumor cells independent of Arf status. Our results demonstrate …
Recombinational DNA repair and human disease.
Thompson LH, Schild D. Thompson LH, et al. Mutat Res. 2002 Nov 30;509(1-2):49-78. doi: 10.1016/s0027-5107(02)00224-5. Mutat Res. 2002. PMID: 12427531 Review.
The breast cancer-associated BRCA1 and BRCA2 proteins are strongly implicated in HRR; BRCA2 associates with Rad51 and appears to regulate its activity. We discuss in detail the phenotypes of the various mutant cell lines and the signaling pathways mediated by the ATM kinas …
The breast cancer-associated BRCA1 and BRCA2 proteins are strongly implicated in HRR; BRCA2 associates with Rad51 and appears to regu …
Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.
Zhou J, Tong F, Zhao J, Cui X, Wang Y, Wang G, Kang C, Liu X, Wang Q. Zhou J, et al. Cancer Biol Med. 2023 Jun 5;20(5):385-400. doi: 10.20892/j.issn.2095-3941.2023.0011. Cancer Biol Med. 2023. PMID: 37283490 Free PMC article.
Western blot, real-time PCR, flow cytometry, and immunofluorescence were used to determine the chemoresistance role of E2F1 and RAD51-associated protein 1 (RAD51AP1). RESULTS: Bioinformatic analysis identified E2F1 as the key transcription factor in EGFRvIII-positive livin …
Western blot, real-time PCR, flow cytometry, and immunofluorescence were used to determine the chemoresistance role of E2F1 and RAD51 …
112 results